bonecancerpain相关论文
骨骼是乳腺癌、前列腺癌等常见癌症晚期好发的转移部位，癌症骨转移通常伴随剧烈的慢性疼痛症状，严重影响患者的生存质量。随着癌症骨......
Neuron-restrictive silencer factor mediated down-regulation of μ-opioid receptor contrbutes to the r
Background: Primary and metastatic cancers that affect bone are frequently associated with severe and intractable pain.B......
Objective Lipoxins represent a unique class of lipid mediators that can function as "braking signals" in inflammation.......
IL-6-mediated functional up-regulation of TRPV1 receptors in DRG neurons via the activation of JAK/P
Objective Primary and metastatic cancers that affect bone are frequently associated with severe and intractable pain....
The treatment of bone cancer pain remains a clinically challenging problem.Here, we report that A-type K+ channels in pr......
Morphine is the most effective analgesic for chronic pain including bone cancer pain.So far,studies on morphine toleranc......
Objective Lysophosphatidic acid(LPA),a lipid metabolite released by injured tissues and tumor,is a key mediator in cance......
In our previous work,a rat model of tibia bone was established by inoculating the Walker 256 rat mammary gland carcinoma......
Bone cancer-induced hypersensitivity is not necessarily correlated with spinal microglial CX3CR1 ove
Objective Pain is one of the most severe symptoms in bone cancer patients.Previous studies have suggested that the activ......
New mechanisms of metastatic bone cancer pain:Cancer tissue-derived endogenous formaldehyde activati
In recent years,our serial investigations focused on the role of cancer cells-derived endogenous formaldehyde in bone ca......
Mitogen-activated protein kinases (MAPK)-mediated chemokine-cytokine networks in glial cells are likely involved in the ......
Bone cancer pain resulting from primary tumors or tumors that metastasize to bone is one of the most severe and intracta......
New mechanisms of metastatic bone cancer pain: cancer tissue-derived ENDOGENOUS formaldehyde activat
In recent years, our serial investigations focused on the role of cancer cells-derived endogenous formaldehyde in bone c......
目的 观察鞘内注射大麻素受体2(CB2)激动剂JWH015对骨癌痛小鼠痛行为的影响.方法 雄性C3H/HeN小鼠32只随机分为4组(n=8):空白组(C)......
目的 在小鼠骨癌痛模型上观察鞘内注射N-甲基-D-天冬氨酸受体2B亚基(NR2B)拮抗剂艾芬地尔的镇痛效果.方法 将含2×105个纤维肉瘤细......
目的 探讨钙/钙调蛋白依赖性蛋白激酶Ⅱ(CaMKⅡ)在骨癌痛发病机制中的作用.方法 雄性C3H/HeN小鼠40只分为5组:假手对照Sham组(S组n......
目的观察不同剂量加巴喷丁对胫骨癌痛大鼠机械痛敏的影响。方法雌性SD大鼠42只，随机分为7组(n＝6)，即空白对照组(N组)、假手术＋生理盐水......
目的 探讨鞘内注射钙/钙调蛋白依赖性蛋白激酶Ⅱ( CaMKII)抑制剂KN93对骨癌痛小鼠脊髓NR2B蛋白表达的影响及机制.方法 SPF级雄性C3......
目的探讨鞘内注射丹参酮ⅡA对骨癌痛小鼠热痛觉过敏及脊髓水平白介素-1β(IL-1β)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)表达......
目的探讨鞘内重复注射驱动蛋白17(Kinesin superfamily 17，KIF17)反义寡核苷酸对骨癌痛小鼠脊髓水平mLin10(mammalian orthologue o......
目的探讨miR-16在骨癌痛大鼠脊髓中表达量的变化规律及鞘内注射miR-16模拟物(miR-16 mimics)对骨癌痛大鼠行为学及其靶基因BDNF表......
目的评价脊髓水平程序性死亡配体1(programmed cell death ligand-1，PD-L1)在骨癌痛小鼠模型中的作用。方法SPF级雄性C3H/HeJ小鼠96......
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目的 骨癌痛是临床最常见的癌症疼痛之一,因缺乏模拟骨癌痛临床发病病理特征的药物研发体内模型,从而不能精准干预其发病过程、优......
